Please use this identifier to cite or link to this item: http://localhost/handle/Hannan/647437
Title: The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities
Authors: Bernard Choi;Wenbin Tan;Wangcun Jia;Sean M. White;Wesley J. Moy;Bruce Y. Yang;Jiang Zhu;Zhongping Chen;Kristen M. Kelly;J. Stuart Nelson
subject: biophotonics|dorsal window chamber|biomedical optical imaging|surgery|intravital imaging|image-guided surgery|anti-angiogenic
Year: 2016
Publisher: IEEE
Abstract: Here, we review our current knowledge on the etiology and treatment of port-wine stain (PWS) birthmarks. Current treatment options have significant limitations in terms of efficacy. With the combination of 1) a suitable preclinical microvascular model, 2) laser speckle imaging (LSI) to evaluate blood-flow dynamics, and 3) a longitudinal experimental design, rapid preclinical assessment of new phototherapies can be translated from the lab to the clinic. The combination of photodynamic therapy (PDT) and pulsed-dye laser (PDL) irradiation achieves a synergistic effect that reduces the required radiant exposures of the individual phototherapies to achieve persistent vascular shutdown. PDL combined with antiangiogenic agents is a promising strategy to achieve persistent vascular shutdown by preventing reformation and reperfusion of photocoagulated blood vessels. Integration of LSI into the clinical workflow may lead to surgical image guidance that maximizes acute photocoagulation, which is expected to improve PWS therapeutic outcome. Continued integration of noninvasive optical imaging technologies and biochemical analysis collectively are expected to lead to more robust treatment strategies.
URI: http://localhost/handle/Hannan/179750
http://localhost/handle/Hannan/647437
ISSN: 1077-260X
1558-4542
volume: 22
issue: 3
Appears in Collections:2016

Files in This Item:
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Title: The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities
Authors: Bernard Choi;Wenbin Tan;Wangcun Jia;Sean M. White;Wesley J. Moy;Bruce Y. Yang;Jiang Zhu;Zhongping Chen;Kristen M. Kelly;J. Stuart Nelson
subject: biophotonics|dorsal window chamber|biomedical optical imaging|surgery|intravital imaging|image-guided surgery|anti-angiogenic
Year: 2016
Publisher: IEEE
Abstract: Here, we review our current knowledge on the etiology and treatment of port-wine stain (PWS) birthmarks. Current treatment options have significant limitations in terms of efficacy. With the combination of 1) a suitable preclinical microvascular model, 2) laser speckle imaging (LSI) to evaluate blood-flow dynamics, and 3) a longitudinal experimental design, rapid preclinical assessment of new phototherapies can be translated from the lab to the clinic. The combination of photodynamic therapy (PDT) and pulsed-dye laser (PDL) irradiation achieves a synergistic effect that reduces the required radiant exposures of the individual phototherapies to achieve persistent vascular shutdown. PDL combined with antiangiogenic agents is a promising strategy to achieve persistent vascular shutdown by preventing reformation and reperfusion of photocoagulated blood vessels. Integration of LSI into the clinical workflow may lead to surgical image guidance that maximizes acute photocoagulation, which is expected to improve PWS therapeutic outcome. Continued integration of noninvasive optical imaging technologies and biochemical analysis collectively are expected to lead to more robust treatment strategies.
URI: http://localhost/handle/Hannan/179750
http://localhost/handle/Hannan/647437
ISSN: 1077-260X
1558-4542
volume: 22
issue: 3
Appears in Collections:2016

Files in This Item:
File Description SizeFormat 
7303894.pdf2.29 MBAdobe PDFThumbnail
Preview File
Title: The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities
Authors: Bernard Choi;Wenbin Tan;Wangcun Jia;Sean M. White;Wesley J. Moy;Bruce Y. Yang;Jiang Zhu;Zhongping Chen;Kristen M. Kelly;J. Stuart Nelson
subject: biophotonics|dorsal window chamber|biomedical optical imaging|surgery|intravital imaging|image-guided surgery|anti-angiogenic
Year: 2016
Publisher: IEEE
Abstract: Here, we review our current knowledge on the etiology and treatment of port-wine stain (PWS) birthmarks. Current treatment options have significant limitations in terms of efficacy. With the combination of 1) a suitable preclinical microvascular model, 2) laser speckle imaging (LSI) to evaluate blood-flow dynamics, and 3) a longitudinal experimental design, rapid preclinical assessment of new phototherapies can be translated from the lab to the clinic. The combination of photodynamic therapy (PDT) and pulsed-dye laser (PDL) irradiation achieves a synergistic effect that reduces the required radiant exposures of the individual phototherapies to achieve persistent vascular shutdown. PDL combined with antiangiogenic agents is a promising strategy to achieve persistent vascular shutdown by preventing reformation and reperfusion of photocoagulated blood vessels. Integration of LSI into the clinical workflow may lead to surgical image guidance that maximizes acute photocoagulation, which is expected to improve PWS therapeutic outcome. Continued integration of noninvasive optical imaging technologies and biochemical analysis collectively are expected to lead to more robust treatment strategies.
URI: http://localhost/handle/Hannan/179750
http://localhost/handle/Hannan/647437
ISSN: 1077-260X
1558-4542
volume: 22
issue: 3
Appears in Collections:2016

Files in This Item:
File Description SizeFormat 
7303894.pdf2.29 MBAdobe PDFThumbnail
Preview File