Please use this identifier to cite or link to this item: http://localhost/handle/Hannan/594293
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dc.contributor.authorYang Lien_US
dc.contributor.authorJianguo Maen_US
dc.contributor.authorK. Heath Martinen_US
dc.contributor.authorMingyue Yuen_US
dc.contributor.authorTeng Maen_US
dc.contributor.authorPaul A. Daytonen_US
dc.contributor.authorXiaoning Jiangen_US
dc.contributor.authorK. Kirk Shungen_US
dc.contributor.authorQifa Zhouen_US
dc.date.accessioned2020-05-20T08:47:20Z-
dc.date.available2020-05-20T08:47:20Z-
dc.date.issued2016en_US
dc.identifier.issn0018-9294en_US
dc.identifier.issn1558-2531en_US
dc.identifier.other10.1109/TBME.2015.2506639en_US
dc.identifier.urihttp://localhost/handle/Hannan/175763en_US
dc.identifier.urihttp://localhost/handle/Hannan/594293-
dc.description.abstractObjective: Superharmonic contrast-enhanced ultrasound imaging, also called acoustic angiography, has previously been used for the imaging of microvasculature. This approach excites microbubble contrast agents near their resonance frequency and receives echoes at nonoverlapping superharmonic bandwidths. No integrated system currently exists could fully support this application. To fulfill this need, an integrated dual-channel transmit/receive system for superharmonic imaging was designed, built, and characterized experimentally. Method: The system was uniquely designed for superharmonic imaging and high-resolution B-mode imaging. A complete ultrasound system including a pulse generator, a data acquisition unit, and a signal processing unit were integrated into a single package. The system was controlled by a field-programmable gate array, on which multiple user-defined modes were implemented. A 6-, 35-MHz dual-frequency dual-element intravascular ultrasound transducer was designed and used for imaging. Result: The system successfully obtained high-resolution B-mode images of coronary artery ex vivo with 45-dB dynamic range. The system was capable of acquiring in vitro superharmonic images of a vasa vasorum mimicking phantom with 30-dB contrast. It could detect a contrast agent filled tissue mimicking tube of 200 μm diameter. Conclusion: For the first time, high-resolution B-mode images and superharmonic images were obtained in an intravascular phantom, made possible by the dedicated integrated system proposed. The system greatly reduced the cost and complexity of the superharmonic imaging intended for preclinical study. Significant: The system showed promise for high-contrast intravascular microvascular imaging, which may have significant importance in assessment of the vasa vasorum associated with atherosclerotic plaques.en_US
dc.publisherIEEEen_US
dc.relation.haspart7349189.pdfen_US
dc.subjectultrasonic transducer|microbubble contrast agent (MCA)|biomedical electronics|field-programmable gate arrays (FPGA)|ultrasonic imaging|intravascular ultrasound (IVUS)|Acoustic angiographyen_US
dc.titleAn Integrated System for Superharmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Studyen_US
dc.typeArticleen_US
dc.journal.volume63en_US
dc.journal.issue9en_US
dc.journal.titleIEEE Transactions on Biomedical Engineeringen_US
Appears in Collections:2016

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Full metadata record
DC FieldValueLanguage
dc.contributor.authorYang Lien_US
dc.contributor.authorJianguo Maen_US
dc.contributor.authorK. Heath Martinen_US
dc.contributor.authorMingyue Yuen_US
dc.contributor.authorTeng Maen_US
dc.contributor.authorPaul A. Daytonen_US
dc.contributor.authorXiaoning Jiangen_US
dc.contributor.authorK. Kirk Shungen_US
dc.contributor.authorQifa Zhouen_US
dc.date.accessioned2020-05-20T08:47:20Z-
dc.date.available2020-05-20T08:47:20Z-
dc.date.issued2016en_US
dc.identifier.issn0018-9294en_US
dc.identifier.issn1558-2531en_US
dc.identifier.other10.1109/TBME.2015.2506639en_US
dc.identifier.urihttp://localhost/handle/Hannan/175763en_US
dc.identifier.urihttp://localhost/handle/Hannan/594293-
dc.description.abstractObjective: Superharmonic contrast-enhanced ultrasound imaging, also called acoustic angiography, has previously been used for the imaging of microvasculature. This approach excites microbubble contrast agents near their resonance frequency and receives echoes at nonoverlapping superharmonic bandwidths. No integrated system currently exists could fully support this application. To fulfill this need, an integrated dual-channel transmit/receive system for superharmonic imaging was designed, built, and characterized experimentally. Method: The system was uniquely designed for superharmonic imaging and high-resolution B-mode imaging. A complete ultrasound system including a pulse generator, a data acquisition unit, and a signal processing unit were integrated into a single package. The system was controlled by a field-programmable gate array, on which multiple user-defined modes were implemented. A 6-, 35-MHz dual-frequency dual-element intravascular ultrasound transducer was designed and used for imaging. Result: The system successfully obtained high-resolution B-mode images of coronary artery ex vivo with 45-dB dynamic range. The system was capable of acquiring in vitro superharmonic images of a vasa vasorum mimicking phantom with 30-dB contrast. It could detect a contrast agent filled tissue mimicking tube of 200 μm diameter. Conclusion: For the first time, high-resolution B-mode images and superharmonic images were obtained in an intravascular phantom, made possible by the dedicated integrated system proposed. The system greatly reduced the cost and complexity of the superharmonic imaging intended for preclinical study. Significant: The system showed promise for high-contrast intravascular microvascular imaging, which may have significant importance in assessment of the vasa vasorum associated with atherosclerotic plaques.en_US
dc.publisherIEEEen_US
dc.relation.haspart7349189.pdfen_US
dc.subjectultrasonic transducer|microbubble contrast agent (MCA)|biomedical electronics|field-programmable gate arrays (FPGA)|ultrasonic imaging|intravascular ultrasound (IVUS)|Acoustic angiographyen_US
dc.titleAn Integrated System for Superharmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Studyen_US
dc.typeArticleen_US
dc.journal.volume63en_US
dc.journal.issue9en_US
dc.journal.titleIEEE Transactions on Biomedical Engineeringen_US
Appears in Collections:2016

Files in This Item:
File Description SizeFormat 
7349189.pdf3.79 MBAdobe PDFThumbnail
Preview File
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYang Lien_US
dc.contributor.authorJianguo Maen_US
dc.contributor.authorK. Heath Martinen_US
dc.contributor.authorMingyue Yuen_US
dc.contributor.authorTeng Maen_US
dc.contributor.authorPaul A. Daytonen_US
dc.contributor.authorXiaoning Jiangen_US
dc.contributor.authorK. Kirk Shungen_US
dc.contributor.authorQifa Zhouen_US
dc.date.accessioned2020-05-20T08:47:20Z-
dc.date.available2020-05-20T08:47:20Z-
dc.date.issued2016en_US
dc.identifier.issn0018-9294en_US
dc.identifier.issn1558-2531en_US
dc.identifier.other10.1109/TBME.2015.2506639en_US
dc.identifier.urihttp://localhost/handle/Hannan/175763en_US
dc.identifier.urihttp://localhost/handle/Hannan/594293-
dc.description.abstractObjective: Superharmonic contrast-enhanced ultrasound imaging, also called acoustic angiography, has previously been used for the imaging of microvasculature. This approach excites microbubble contrast agents near their resonance frequency and receives echoes at nonoverlapping superharmonic bandwidths. No integrated system currently exists could fully support this application. To fulfill this need, an integrated dual-channel transmit/receive system for superharmonic imaging was designed, built, and characterized experimentally. Method: The system was uniquely designed for superharmonic imaging and high-resolution B-mode imaging. A complete ultrasound system including a pulse generator, a data acquisition unit, and a signal processing unit were integrated into a single package. The system was controlled by a field-programmable gate array, on which multiple user-defined modes were implemented. A 6-, 35-MHz dual-frequency dual-element intravascular ultrasound transducer was designed and used for imaging. Result: The system successfully obtained high-resolution B-mode images of coronary artery ex vivo with 45-dB dynamic range. The system was capable of acquiring in vitro superharmonic images of a vasa vasorum mimicking phantom with 30-dB contrast. It could detect a contrast agent filled tissue mimicking tube of 200 μm diameter. Conclusion: For the first time, high-resolution B-mode images and superharmonic images were obtained in an intravascular phantom, made possible by the dedicated integrated system proposed. The system greatly reduced the cost and complexity of the superharmonic imaging intended for preclinical study. Significant: The system showed promise for high-contrast intravascular microvascular imaging, which may have significant importance in assessment of the vasa vasorum associated with atherosclerotic plaques.en_US
dc.publisherIEEEen_US
dc.relation.haspart7349189.pdfen_US
dc.subjectultrasonic transducer|microbubble contrast agent (MCA)|biomedical electronics|field-programmable gate arrays (FPGA)|ultrasonic imaging|intravascular ultrasound (IVUS)|Acoustic angiographyen_US
dc.titleAn Integrated System for Superharmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Studyen_US
dc.typeArticleen_US
dc.journal.volume63en_US
dc.journal.issue9en_US
dc.journal.titleIEEE Transactions on Biomedical Engineeringen_US
Appears in Collections:2016

Files in This Item:
File Description SizeFormat 
7349189.pdf3.79 MBAdobe PDFThumbnail
Preview File