Please use this identifier to cite or link to this item: http://dlib.scu.ac.ir/handle/Hannan/720686
Title: Immune genes are hotspots of shared positive selection across birds and mammals
subject: General Biochemistry, Genetics and Molecular Biology;General Immunology and Microbiology;General Neuroscience;General Medicine
Publisher: eLife Sciences Publications, Ltd
Description: Consistent patterns of positive selection in functionally similar genes can suggest a common selective pressure across a group of species. We use alignments of orthologous protein-coding genes from 39 species of birds to estimate parameters related to positive selection for 11,000 genes conserved across birds. We show that functional pathways related to the immune system, recombination, lipid metabolism, and phototransduction are enriched for positively selected genes. By comparing our results with mammalian data, we find a significant enrichment for positively selected genes shared between taxa, and that these shared selected genes are enriched for viral immune pathways. Using pathogen-challenge transcriptome data, we show that genes up-regulated in response to pathogens are also enriched for positively selected genes. Together, our results suggest that pathogens, particularly viruses, consistently target the same genes across divergent clades, and that these genes are hotspots of host-pathogen conflict over deep evolutionary time.
Organismic and Evolutionary Biology
Version of Record
URI: http://dlib.scu.ac.ir/handle/Hannan/720686
http://nrs.harvard.edu/urn-3:HUL.InstRepos:38447662
More Information: Shultz, Allison J, and Timothy B Sackton. 2019. "Immune Genes Are Hotspots of Shared Positive Selection across Birds and Mammals." ELife 8: 1-33
2050-084X
10.7554/elife.41815
Appears in Collections:Faculty of Arts and Sciences

Files in This Item:
Click on the URI links for accessing contents.
Title: Immune genes are hotspots of shared positive selection across birds and mammals
subject: General Biochemistry, Genetics and Molecular Biology;General Immunology and Microbiology;General Neuroscience;General Medicine
Publisher: eLife Sciences Publications, Ltd
Description: Consistent patterns of positive selection in functionally similar genes can suggest a common selective pressure across a group of species. We use alignments of orthologous protein-coding genes from 39 species of birds to estimate parameters related to positive selection for 11,000 genes conserved across birds. We show that functional pathways related to the immune system, recombination, lipid metabolism, and phototransduction are enriched for positively selected genes. By comparing our results with mammalian data, we find a significant enrichment for positively selected genes shared between taxa, and that these shared selected genes are enriched for viral immune pathways. Using pathogen-challenge transcriptome data, we show that genes up-regulated in response to pathogens are also enriched for positively selected genes. Together, our results suggest that pathogens, particularly viruses, consistently target the same genes across divergent clades, and that these genes are hotspots of host-pathogen conflict over deep evolutionary time.
Organismic and Evolutionary Biology
Version of Record
URI: http://dlib.scu.ac.ir/handle/Hannan/720686
http://nrs.harvard.edu/urn-3:HUL.InstRepos:38447662
More Information: Shultz, Allison J, and Timothy B Sackton. 2019. "Immune Genes Are Hotspots of Shared Positive Selection across Birds and Mammals." ELife 8: 1-33
2050-084X
10.7554/elife.41815
Appears in Collections:Faculty of Arts and Sciences

Files in This Item:
Click on the URI links for accessing contents.
Title: Immune genes are hotspots of shared positive selection across birds and mammals
subject: General Biochemistry, Genetics and Molecular Biology;General Immunology and Microbiology;General Neuroscience;General Medicine
Publisher: eLife Sciences Publications, Ltd
Description: Consistent patterns of positive selection in functionally similar genes can suggest a common selective pressure across a group of species. We use alignments of orthologous protein-coding genes from 39 species of birds to estimate parameters related to positive selection for 11,000 genes conserved across birds. We show that functional pathways related to the immune system, recombination, lipid metabolism, and phototransduction are enriched for positively selected genes. By comparing our results with mammalian data, we find a significant enrichment for positively selected genes shared between taxa, and that these shared selected genes are enriched for viral immune pathways. Using pathogen-challenge transcriptome data, we show that genes up-regulated in response to pathogens are also enriched for positively selected genes. Together, our results suggest that pathogens, particularly viruses, consistently target the same genes across divergent clades, and that these genes are hotspots of host-pathogen conflict over deep evolutionary time.
Organismic and Evolutionary Biology
Version of Record
URI: http://dlib.scu.ac.ir/handle/Hannan/720686
http://nrs.harvard.edu/urn-3:HUL.InstRepos:38447662
More Information: Shultz, Allison J, and Timothy B Sackton. 2019. "Immune Genes Are Hotspots of Shared Positive Selection across Birds and Mammals." ELife 8: 1-33
2050-084X
10.7554/elife.41815
Appears in Collections:Faculty of Arts and Sciences

Files in This Item:
Click on the URI links for accessing contents.