Please use this identifier to cite or link to this item: http://dlib.scu.ac.ir/handle/2027.42/24899
Title: A proposal for the clinical use of flecainide
Authors: University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA; University of Michigan School of Medicine, Ann Arbor, Michigan, USA.;University of Michigan School of Medicine, Ann Arbor, Michigan, USA; University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA.;University of Michigan School of Medicine, Ann Arbor, Michigan, USA; University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA.
Publisher: Elsevier
Description: Effective antiarrhythmic therapy requires a carefully considered approach, including an understanding of the arrhythmia, the underlying cardiac disease and the drug's pharmacokinetics. Flecainide is a new antiarrhythmic drug that may soon be released for general use. Flecainide demonstrates unsurpassed efficacy in chronic ventricular arrhythmias in stable patients and may become a first-choice drug because of its ease of administration, efficacy and favorable tolerance. Twice-daily dosing with 100 to 200 mg usually provides effective therapy. Clinical experience suggests flecainide to be indicated in the treatment of uniform and multiform ventricular premature complexes, coupled ventricular premature complexes, and episodes of nonsustained ventricular tachycardia. A lower response rate is observed in preventing induction of sustained ventricular tachycardia, and these patients should be carefully selected. Flecainide is promising in the treatment of supraventricular tachycardias using atrioventricular nodal or extranodal reentrant pathways, although this use is still investigational in the United States. The drug's use for arrhythmias during acute myocardial infarction requires further study. Flecainide possesses modest negative inotropic potential. Proarrhythmic or other adverse reactions have occurred primarily in settings of high drug level, poor ventricular function or refractory, malignant arrhythmias, suggesting caution in these groups.
URI: https://deepblue.lib.umich.edu/handle/2027.42/24899
More Information: Anderson, Jeffrey L., Stewart, James R., Crevey, Barry J. (1984/02/27)."A proposal for the clinical use of flecainide." The American Journal of Cardiology 53(5): B112-B119. <http://hdl.handle.net/2027.42/24899>
http://www.sciencedirect.com/science/article/B6T10-4BW0T0T-28T/2/2c4f9e0d11fadba00ff530bc89a4443a
http://hdl.handle.net/2027.42/24899
http://dx.doi.org/10.1016/0002-9149(84)90514-9
The American Journal of Cardiology
Appears in Collections:Research Collections

Files in This Item:
Click on the URI links for accessing contents.
Title: A proposal for the clinical use of flecainide
Authors: University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA; University of Michigan School of Medicine, Ann Arbor, Michigan, USA.;University of Michigan School of Medicine, Ann Arbor, Michigan, USA; University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA.;University of Michigan School of Medicine, Ann Arbor, Michigan, USA; University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA.
Publisher: Elsevier
Description: Effective antiarrhythmic therapy requires a carefully considered approach, including an understanding of the arrhythmia, the underlying cardiac disease and the drug's pharmacokinetics. Flecainide is a new antiarrhythmic drug that may soon be released for general use. Flecainide demonstrates unsurpassed efficacy in chronic ventricular arrhythmias in stable patients and may become a first-choice drug because of its ease of administration, efficacy and favorable tolerance. Twice-daily dosing with 100 to 200 mg usually provides effective therapy. Clinical experience suggests flecainide to be indicated in the treatment of uniform and multiform ventricular premature complexes, coupled ventricular premature complexes, and episodes of nonsustained ventricular tachycardia. A lower response rate is observed in preventing induction of sustained ventricular tachycardia, and these patients should be carefully selected. Flecainide is promising in the treatment of supraventricular tachycardias using atrioventricular nodal or extranodal reentrant pathways, although this use is still investigational in the United States. The drug's use for arrhythmias during acute myocardial infarction requires further study. Flecainide possesses modest negative inotropic potential. Proarrhythmic or other adverse reactions have occurred primarily in settings of high drug level, poor ventricular function or refractory, malignant arrhythmias, suggesting caution in these groups.
URI: https://deepblue.lib.umich.edu/handle/2027.42/24899
More Information: Anderson, Jeffrey L., Stewart, James R., Crevey, Barry J. (1984/02/27)."A proposal for the clinical use of flecainide." The American Journal of Cardiology 53(5): B112-B119. <http://hdl.handle.net/2027.42/24899>
http://www.sciencedirect.com/science/article/B6T10-4BW0T0T-28T/2/2c4f9e0d11fadba00ff530bc89a4443a
http://hdl.handle.net/2027.42/24899
http://dx.doi.org/10.1016/0002-9149(84)90514-9
The American Journal of Cardiology
Appears in Collections:Research Collections

Files in This Item:
Click on the URI links for accessing contents.
Title: A proposal for the clinical use of flecainide
Authors: University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA; University of Michigan School of Medicine, Ann Arbor, Michigan, USA.;University of Michigan School of Medicine, Ann Arbor, Michigan, USA; University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA.;University of Michigan School of Medicine, Ann Arbor, Michigan, USA; University of Utah College of Medicine, Division of Cardiology, Salt Lake City, Utah, USA.
Publisher: Elsevier
Description: Effective antiarrhythmic therapy requires a carefully considered approach, including an understanding of the arrhythmia, the underlying cardiac disease and the drug's pharmacokinetics. Flecainide is a new antiarrhythmic drug that may soon be released for general use. Flecainide demonstrates unsurpassed efficacy in chronic ventricular arrhythmias in stable patients and may become a first-choice drug because of its ease of administration, efficacy and favorable tolerance. Twice-daily dosing with 100 to 200 mg usually provides effective therapy. Clinical experience suggests flecainide to be indicated in the treatment of uniform and multiform ventricular premature complexes, coupled ventricular premature complexes, and episodes of nonsustained ventricular tachycardia. A lower response rate is observed in preventing induction of sustained ventricular tachycardia, and these patients should be carefully selected. Flecainide is promising in the treatment of supraventricular tachycardias using atrioventricular nodal or extranodal reentrant pathways, although this use is still investigational in the United States. The drug's use for arrhythmias during acute myocardial infarction requires further study. Flecainide possesses modest negative inotropic potential. Proarrhythmic or other adverse reactions have occurred primarily in settings of high drug level, poor ventricular function or refractory, malignant arrhythmias, suggesting caution in these groups.
URI: https://deepblue.lib.umich.edu/handle/2027.42/24899
More Information: Anderson, Jeffrey L., Stewart, James R., Crevey, Barry J. (1984/02/27)."A proposal for the clinical use of flecainide." The American Journal of Cardiology 53(5): B112-B119. <http://hdl.handle.net/2027.42/24899>
http://www.sciencedirect.com/science/article/B6T10-4BW0T0T-28T/2/2c4f9e0d11fadba00ff530bc89a4443a
http://hdl.handle.net/2027.42/24899
http://dx.doi.org/10.1016/0002-9149(84)90514-9
The American Journal of Cardiology
Appears in Collections:Research Collections

Files in This Item:
Click on the URI links for accessing contents.