Please use this identifier to cite or link to this item: http://dlib.scu.ac.ir/handle/2027.42/24891
Title: Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat
Authors: Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.
Publisher: Elsevier
Description: The ability of gastrocnemius muscle homogenates to catalyze the oxidation of succinate, glutamate + malate, pyruvate + malate, palmitoyl-coenzyme A, decanoylcarnitine and palmitoylcarnitine in the presence of ADP decreased by approximately 32% in sedentary male Sprague-Dawley rats between the ages of 9 and 25 months. Following 21 weeks of treadmill training (running), such homogenates from 25-month-old animals catalyzed oxidations 55% more rapidly than those from 25-month-old sedentary rats, and 17% faster than those from 9-month-old sedentary rats. Total and peptide-bound flavin of gastrocnemius muscles also declined between 9 and 25 months of age and were elevated in the 25-month-old endurance trained rats to levels greater than both 9- and 25-month-old sedentary animals. The yield of protein in the mitochondrial fraction from the quadriceps femoris muscle decreased between 9 and 25 months and was restored to the 9-month level by endurance training. The kinetic characteristics of the isolated mitochondria were not influenced by age or exercise. These data indicate that 2-year-old rats retain the capacity to increase skeletal muscle oxidative capacity and mitochondrial population density in response to endurance training.
URI: https://deepblue.lib.umich.edu/handle/2027.42/24891
More Information: Beyer, Robert E., Starnes, Joseph W., Edington, Dee W., Lipton, Richard J., Compton, III, Ralph T., Kwasman, Michael A. (1984/03)."Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat." Mechanisms of Ageing and Development 24(3): 309-323. <http://hdl.handle.net/2027.42/24891>
http://www.sciencedirect.com/science/article/B6T31-47PG2MF-CH/2/c70111b2c4c351bf5f4f94506b5c21e3
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6717094&dopt=citation
http://hdl.handle.net/2027.42/24891
6717094
http://dx.doi.org/10.1016/0047-6374(84)90116-7
Mechanisms of Ageing and Development
Appears in Collections:Research Collections

Files in This Item:
Click on the URI links for accessing contents.
Title: Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat
Authors: Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.
Publisher: Elsevier
Description: The ability of gastrocnemius muscle homogenates to catalyze the oxidation of succinate, glutamate + malate, pyruvate + malate, palmitoyl-coenzyme A, decanoylcarnitine and palmitoylcarnitine in the presence of ADP decreased by approximately 32% in sedentary male Sprague-Dawley rats between the ages of 9 and 25 months. Following 21 weeks of treadmill training (running), such homogenates from 25-month-old animals catalyzed oxidations 55% more rapidly than those from 25-month-old sedentary rats, and 17% faster than those from 9-month-old sedentary rats. Total and peptide-bound flavin of gastrocnemius muscles also declined between 9 and 25 months of age and were elevated in the 25-month-old endurance trained rats to levels greater than both 9- and 25-month-old sedentary animals. The yield of protein in the mitochondrial fraction from the quadriceps femoris muscle decreased between 9 and 25 months and was restored to the 9-month level by endurance training. The kinetic characteristics of the isolated mitochondria were not influenced by age or exercise. These data indicate that 2-year-old rats retain the capacity to increase skeletal muscle oxidative capacity and mitochondrial population density in response to endurance training.
URI: https://deepblue.lib.umich.edu/handle/2027.42/24891
More Information: Beyer, Robert E., Starnes, Joseph W., Edington, Dee W., Lipton, Richard J., Compton, III, Ralph T., Kwasman, Michael A. (1984/03)."Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat." Mechanisms of Ageing and Development 24(3): 309-323. <http://hdl.handle.net/2027.42/24891>
http://www.sciencedirect.com/science/article/B6T31-47PG2MF-CH/2/c70111b2c4c351bf5f4f94506b5c21e3
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6717094&dopt=citation
http://hdl.handle.net/2027.42/24891
6717094
http://dx.doi.org/10.1016/0047-6374(84)90116-7
Mechanisms of Ageing and Development
Appears in Collections:Research Collections

Files in This Item:
Click on the URI links for accessing contents.
Title: Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat
Authors: Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.;Laboratory of Chemical Biology, Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, Ann Arbor, MI 48109, U.S.A.; Department of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, U.S.A.
Publisher: Elsevier
Description: The ability of gastrocnemius muscle homogenates to catalyze the oxidation of succinate, glutamate + malate, pyruvate + malate, palmitoyl-coenzyme A, decanoylcarnitine and palmitoylcarnitine in the presence of ADP decreased by approximately 32% in sedentary male Sprague-Dawley rats between the ages of 9 and 25 months. Following 21 weeks of treadmill training (running), such homogenates from 25-month-old animals catalyzed oxidations 55% more rapidly than those from 25-month-old sedentary rats, and 17% faster than those from 9-month-old sedentary rats. Total and peptide-bound flavin of gastrocnemius muscles also declined between 9 and 25 months of age and were elevated in the 25-month-old endurance trained rats to levels greater than both 9- and 25-month-old sedentary animals. The yield of protein in the mitochondrial fraction from the quadriceps femoris muscle decreased between 9 and 25 months and was restored to the 9-month level by endurance training. The kinetic characteristics of the isolated mitochondria were not influenced by age or exercise. These data indicate that 2-year-old rats retain the capacity to increase skeletal muscle oxidative capacity and mitochondrial population density in response to endurance training.
URI: https://deepblue.lib.umich.edu/handle/2027.42/24891
More Information: Beyer, Robert E., Starnes, Joseph W., Edington, Dee W., Lipton, Richard J., Compton, III, Ralph T., Kwasman, Michael A. (1984/03)."Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat." Mechanisms of Ageing and Development 24(3): 309-323. <http://hdl.handle.net/2027.42/24891>
http://www.sciencedirect.com/science/article/B6T31-47PG2MF-CH/2/c70111b2c4c351bf5f4f94506b5c21e3
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6717094&dopt=citation
http://hdl.handle.net/2027.42/24891
6717094
http://dx.doi.org/10.1016/0047-6374(84)90116-7
Mechanisms of Ageing and Development
Appears in Collections:Research Collections

Files in This Item:
Click on the URI links for accessing contents.